Evidence map›Paper›PMID 42812670›Full record

SynthesisJournal of biomedical optics2026

Unifying the spectrum: a framework for the meta-analysis of human skin tone scales.

Amir S Bernat, Lea Bromberg, David Sinefeld, Boaz Arad

Abstract readMeta-Analysis
In one paragraph

Synthesis in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amir S BernatVoyage81 LTD, Tel-Aviv, Israel.
Lea BrombergVoyage81 LTD, Tel-Aviv, Israel.
David SinefeldVoyage81 LTD, Tel-Aviv, Israel.
Boaz AradVoyage81 LTD, Tel-Aviv, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Quantification of human skin tone is fundamental to dermatology, medical imaging, computer vision, and social studies. However, the field currently lacks a standardized framework, relying on fragmented methodologies, from the Fitzpatrick skin phototype (FST) to the Monk skin tone (MST) scale. Even nowadays, this creates barriers to scientific progress and introduces systemic errors and bias in medical devices and AI fairness. Aim: The aim of this study is to establish a meta-analytic framework, termed a "scale of scales," to critically assess and quantitatively compare the interoperability and accuracy of prevailing skin tone quantification systems. Approach: We utilized the International Skin Spectra Archive (ISSA), composed of 15,256 spectral reflectance measurements from a globally diverse population, as a biological baseline. We overlaid the categories of major verbal, physical, and digital scales onto this dataset to evaluate their coverage and fidelity. Results: Our analysis reveals that widely used scales such as FST and MST fail to capture the continuous, multidimensional nature of human pigmentation. Furthermore, physical targets such as the Pantone skintone guide exhibit significant metameric failure, rendering them unreliable under varying illumination. Conclusions: Current subjective and categorical proxies are insufficient for robust scientific application. The field must transition toward a unified, data-driven framework rooted in spectral reflectance data to ensure interoperability and inclusivity in medical and technical applications.

Indexed as

Skin PigmentationHumansReference StandardsReference ValuesSkinSpectrum AnalysiscolorimetrycolorismFitzpatrick scalemonk scaleskin colorskin toneskin tone scales

Identifiers

PMID42812670
PMCPMC13621389

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.