ArticleClinical nephrology. Case studies2026
New-onset lupus nephritis and neuropsychiatric lupus following COVID-19 vaccination: A case report.
Article in Clinical nephrology. Case studies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although COVID-19 mRNA vaccines have demonstrated excellent safety profiles, rare autoimmune complications - including new-onset systemic lupus erythematosus (SLE) and lupus nephritis (LN) - have been reported. We describe a case of new-onset class IV LN with neuropsychiatric lupus (NPSLE) occurring shortly after COVID-19 vaccination in a previously healthy adult. This case highlights a rare presentation of new-onset SLE manifesting with both severe renal and neuropsychiatric involvement following COVID-19 mRNA vaccination. While causality cannot be established, the temporal association and absence of alternative triggers suggest vaccine-induced immune dysregulation as a potential precipitating factor. Awareness of such atypical presentations may facilitate earlier diagnosis and management, although these events remain exceedingly uncommon relative to the overwhelming benefits of vaccination.
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