Evidence map›Paper›PMID 42812630›Full record

ArticleFrontiers in genome editing2026

R2Tg retrotransposon mediated targeted integration of exogenous genes into the 28S rDNA locus in mammalian cell lines for PKU gene therapy.

Xiuyuan Wang, Ziqi Wen, Rongjun Xu, Wenjing Shi, Yiling Long, Xingri Zhan, Rui Su, Jia Fei, Yumin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genome editing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiuyuan Wang *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China.
Ziqi Wen *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China.
Rongjun Xu *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China.
Wenjing Shi *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China.
Yiling LongState Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China.
Xingri ZhanState Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China.
Rui SuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China.
Jia FeiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China.
Yumin LiMedical Laboratory of the Third Affiliated Hospital of Shenzhen University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenylketonuria (PKU) remains a challenging genetic disorder due to the absence of therapeutic strategies capable of achieving sustained restoration of phenylalanine hydroxylase (PAH) function. Here, we employed an R2 retrotransposon in

Indexed as

28S rDNAphenylalanine hydroxylase (PAH) mRNAphenylketonuria (PKU)R2 retrotransposon in Taeniopygia guttata (R2Tg)targeted gene integrationtarget-primed reverse transcription (TPRT)

Identifiers

PMID42812630
PMCPMC13621248

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.