ArticleInternational journal of breast cancer2026
Risk Factors for Persistent Lymphedema Following Modified Axillary Lymph Node Dissection in Breast Cancer Patients: A Retrospective Single-Center Study.
Article in International journal of breast cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Persistent lymphedema (PLE) is a common complication following breast cancer surgery, particularly after axillary lymph node dissection (ALND). It significantly impacts the quality of life and daily functioning of survivors. Understanding the risk factors for PLE is crucial for early detection and effective management. Purpose: This study is aimed at identifying the risk factors for PLE following modified ALND in breast cancer patients, focusing on clinical, surgical, and molecular characteristics. Methods: A retrospective, single-center study was conducted on women who underwent breast cancer surgery between 2018 and 2021. Demographic, clinical, and treatment-related data were collected from medical records. Univariable and multivariable logistic regression analyses were performed to identify risk factors for PLE. Results: Of the 150 patients, 31 (21.4%) developed PLE. Significant risk factors for PLE included metastasis ( Conclusions: Metastasis, surgery type, chemotherapy, and molecular factors such as ER and Ki-67 expression showed unadjusted associations with PLE. However, in multivariable logistic regression, metastasis remained the only independent predictor of PLE. These findings support risk-stratified postoperative surveillance, and larger prospective studies with standardized lymphedema measurement are needed to validate independent predictors.
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