Evidence map›Paper›PMID 42812586›Full record

ArticleFrontiers in cellular and infection microbiology2026

A broad-host-range inhalable phage cocktail for treatment of multidrug-resistant

Zixun Lin, Xiaofu Wan, Xiangke Duan, Shuang Liang, Xiaoqian Wang, Jiuxin Qu, Chuandong Zhou, Min Ming, Yukun Zeng, Shuhong Han and 7 more

Abstract read
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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zixun Lin *National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Xiaofu Wan *National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Xiangke Duan *National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Shuang LiangCollege of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China.
Xiaoqian WangCollege of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China.
Jiuxin QuNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Chuandong ZhouNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Min MingNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Yukun ZengNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Shuhong HanNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Yijia LingNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Wenheng GanNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Ke WangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Liang YangNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Xin ZhouCollege of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China.
Hongzhou LuNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.
Jiayin ShenNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The growing threat of multidrug-resistant (MDR) Methods: We constructed a seven-phage cocktail by selecting phages with complementary host ranges, strong lytic activity, and different receptor targets. The antimicrobial and anti-biofilm activity of the cocktail was assessed Results: The phage cocktail demonstrated lytic activity against nearly 90% of 152 clinical Conclusion: High-dose nebulized administration of this phage cocktail reduced bacterial burden and showed favorable tolerability in a murine model of MDR

Indexed as

BacteriophagesDrug Resistance, Multiple, BacterialHost SpecificityPhage TherapyPneumonia, BacterialPseudomonas aeruginosaPseudomonas InfectionsPseudomonas PhagesRespiratory Tract InfectionsAdministration, InhalationAnimalsAnti-Bacterial AgentsBacterial LoadBiofilmsDisease Models, AnimalFemaleAnti-Bacterial Agentsbacteriophage therapybroad-host-range phageinhalation deliverymultidrug-resistant Pseudomonas aeruginosaphage cocktail

Identifiers

PMID42812586
PMCPMC13619946

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.