Evidence map›Paper›PMID 42812567›Full record

ArticleFrontiers in microbiology2026

Natural variations at the E433 site in Env-gp120 β20-β21 cooperate with V2 and gp41 mutations to modulate HIV-1 infectivity.

Bao Quoc Le, Khanh Quoc Tran, Naoya Doi, Takaaki Koma, Tomoyuki Kondo, Osamu Kotani, Hironori Sato, Shun Adachi, Akio Adachi, Masaru Yokoyama and 1 more

Abstract read
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In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bao Quoc Le *Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Khanh Quoc Tran *Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Naoya Doi *Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Takaaki KomaDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Tomoyuki KondoDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Osamu KotaniDepartment of Bioinformatics and Integrative Omics, National Institute of Infectious Diseases, Japan Institute for Health Security, Musashimurayama, Japan.
Hironori SatoDepartment of Bioinformatics and Integrative Omics, National Institute of Infectious Diseases, Japan Institute for Health Security, Musashimurayama, Japan.
Shun AdachiIndependent Researcher, Uji, Japan.
Akio AdachiDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
Masaru YokoyamaDepartment of Bioinformatics and Integrative Omics, National Institute of Infectious Diseases, Japan Institute for Health Security, Musashimurayama, Japan.
Masako NomaguchiDepartment of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-1 infection begins with Env-gp120 binding to the CD4 receptor and CD4-triggered Env conformational changes that enable viral entry. To identify key Env sites that modulate Env-CD4 interactions, we analyzed growth-enhanced adaptive mutants generated through the

Indexed as

adaptive mutationsCD4 interactionEnvHIV-1β20-β21 hairpin

Identifiers

PMID42812567
PMCPMC13619938

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.