ArticleJournal of inflammation research2026
Vitamin B12 Alleviates Hepatic Ischemia-Reperfusion Injury with Restoration of Propanoate Metabolism and Mitochondrial Function.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hepatic ischemia-reperfusion injury (HIRI) is a major cause of liver dysfunction after hepatectomy and liver transplantation and involves inflammatory, oxidative, mitochondrial, and metabolic disturbances. Although inflammatory and oxidative mechanisms have been extensively studied, metabolic alterations during HIRI remain less well characterized. This study investigated changes in propanoate metabolism during HIRI and evaluated the effects of vitamin B12 (VB12). Methods: Transcriptomic and single-cell transcriptomic data from mouse HIRI models and human liver transplantation were integrated with in vivo experiments and hypoxia/reoxygenation (H/R) experiments in AML12 cells to examine changes in propanoate metabolism and the effects of VB12 treatment. Results: Propanoate metabolism was markedly suppressed during HIRI, with a similar reduction observed in hepatocytes from human liver transplantation data. VB12 treatment reduced H/R and HIRI induced injury and inflammatory responses in vitro and in vivo. Transcriptomic analysis showed recovery of propanoate metabolism-related pathways after VB12 treatment. Among the candidate genes identified within this pathway, Conclusion: Hepatocyte propanoate metabolism is markedly suppressed during HIRI. VB12 restores propanoate metabolism and Mmut expression, improves mitochondrial function, and alleviates HIRI. These findings identify
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