Evidence map›Paper›PMID 42812546›Full record

ArticleJournal of biomedical optics2026

Histopathological analysis for human articular cartilage using a Raman probe system.

Hiroshi Kiyomatsu, Kosuke Toda, Takashi Katagiri, Akinori Taketani, Kaori Sugiyama, Tatsuhiko Kutsuna, Tomofumi Kinoshita, Takashi Tsuda, Masaki Takao, Yusuke Oshima

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hiroshi KiyomatsuEhime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan.
Kosuke TodaUniversity of Toyama, Graduate School of Pharma-Medical Sciences, Toyama, Japan.
Takashi KatagiriUniversity of Toyama, Research Center for Pre-Disease Science, Toyama, Japan.
Akinori TaketaniUniversity of Toyama, Faculty of Engineering, Toyama, Japan.
Kaori SugiyamaUniversity of Toyama, Research Center for Pre-Disease Science, Toyama, Japan.
Tatsuhiko KutsunaEhime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan.ORCID https://orcid.org/0000-0002-1004-6315
Tomofumi KinoshitaEhime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan.
Takashi TsudaEhime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan.
Masaki TakaoEhime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan.
Yusuke OshimaUniversity of Toyama, Research Center for Pre-Disease Science, Toyama, Japan.ORCID https://orcid.org/0000-0002-2304-8600

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: The molecular pathogenesis of degenerative alterations in articular cartilage is still not fully understood. Raman spectroscopy using a fiber-optic probe system is a promising approach for the early diagnosis and prevention of joint disorders such as osteoarthritis. Aim: This study aims to characterize the degenerative changes in the joint articular cartilage using a hollow-core fiber Raman probe designed for future arthroscopic use. Approach: Human articular cartilage specimens were obtained from 12 patients who underwent knee ( Results: The hollow-core fiber Raman probe detected molecular differences between less-degenerated and degenerated areas in human shoulder and knee articular cartilage Conclusions: These results support the novelty and translational potential of this probe as a future

Indexed as

Cartilage, ArticularSpectrum Analysis, RamanAgedEquipment DesignFemaleFiber Optic TechnologyHumansKnee JointMaleMiddle AgedOsteoarthritisShoulder Jointjoint cartilageosteoarthritisraman proberaman spectroscopy

Identifiers

PMID42812546
PMCPMC13620353

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.