Evidence map›Paper›PMID 42812466›Full record

ReviewSleep and biological rhythms2026

Association between restless legs syndrome and erectile dysfunction: a systematic review and meta-analysis.

Rafael Matos Vieira Gordilho, Nilo Jorge Carvalho Leão Barreto, Felipe Pinho E Albuquerque Silva, João Victor Pereira Gonzalez, Nathalia Pedreira Santos de Lemos, Kenzo Ogasawara Donato, Paula Alana Morais Seixas, Gabriela Nunes E Brito, Henrique Brasileiro Terceiro, Felipe Pereira Garrido Pazos and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sleep and biological rhythms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rafael Matos Vieira GordilhoBrazilian Institute of Robotic Surgery, CME - Medical and Business Center, Av. Anita Garibaldi 1815, Suite 219, Block B, Ondina, Salvador, 40170-130 Bahia Brazil.ORCID 0009-0003-9214-7906
Nilo Jorge Carvalho Leão BarretoBrazilian Institute of Robotic Surgery, CME - Medical and Business Center, Av. Anita Garibaldi 1815, Suite 219, Block B, Ondina, Salvador, 40170-130 Bahia Brazil.
Felipe Pinho E Albuquerque SilvaBrazilian Institute of Robotic Surgery, CME - Medical and Business Center, Av. Anita Garibaldi 1815, Suite 219, Block B, Ondina, Salvador, 40170-130 Bahia Brazil.
João Victor Pereira GonzalezBahiana School of Medicine and Public Health, Av. Dom João VI 275, Brotas, Salvador, 40290-000 Bahia Brazil.
Nathalia Pedreira Santos de LemosBahiana School of Medicine and Public Health, Av. Dom João VI 275, Brotas, Salvador, 40290-000 Bahia Brazil.
Kenzo Ogasawara DonatoBahiana School of Medicine and Public Health, Av. Dom João VI 275, Brotas, Salvador, 40290-000 Bahia Brazil.
Paula Alana Morais SeixasBahiana School of Medicine and Public Health, Av. Dom João VI 275, Brotas, Salvador, 40290-000 Bahia Brazil.
Gabriela Nunes E BritoBahiana School of Medicine and Public Health, Av. Dom João VI 275, Brotas, Salvador, 40290-000 Bahia Brazil.
Henrique Brasileiro TerceiroBahiana School of Medicine and Public Health, Av. Dom João VI 275, Brotas, Salvador, 40290-000 Bahia Brazil.
Felipe Pereira Garrido PazosBrazilian Institute of Robotic Surgery, CME - Medical and Business Center, Av. Anita Garibaldi 1815, Suite 219, Block B, Ondina, Salvador, 40170-130 Bahia Brazil.
Rodrigo Barbosa Freire SilvãoBrazilian Institute of Robotic Surgery, CME - Medical and Business Center, Av. Anita Garibaldi 1815, Suite 219, Block B, Ondina, Salvador, 40170-130 Bahia Brazil.
Cristina SallesBahiana School of Medicine and Public Health, Av. Dom João VI 275, Brotas, Salvador, 40290-000 Bahia Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate whether patients with RLS have increased odds of ED compared with non-RLS controls. Methods: We conducted a systematic review and meta-analysis analyzing the odds of ED in patients with RLS. We included studies that: (i) evaluated adults with a diagnosis of RLS established by the pre-established criteria; (ii) included a control group without RLS; and (iii) evaluated outcomes related to the odds of ED in patients with RLS. We followed the PRISMA 2020 protocol. Results: This systematic review included a total sample of 33,740 participants. Patients with RLS had 70% higher odds of ED compared with non-RLS controls (OR = 1.70; 95% CI: 1.52-1.91; Conclusion: Individuals with RLS have 70% higher odds of ED compared with non-RLS controls. Severe ED was more frequent among patients with RLS, while no significant differences were observed for mild or moderate ED. These findings support ED screening in patients with RLS. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s41105-026-00674-4.

Indexed as

Erectile dysfunctionMenRestless legs syndromeSexual dysfunctionSleep disorders

Identifiers

PMID42812466
PMCPMC13619993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.