ArticleJournal of rheumatic diseases2026
Trends in systemic lupus erythematosus incidence and prevalence among Korean women of childbearing age: a nationwide study 2011~2020.
Article in Journal of rheumatic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Despite advances in systemic lupus erythematosus (SLE) care, the disease remains a significant burden for women of childbearing age. This study assessed trends in SLE incidence and prevalence among women of childbearing age from 2011 to 2020, comparing the periods 2011~2015 and 2016~2020. Methods: Women aged 20~49 with SLE were identified from National Health Insurance Service-National Health Information Database (2009~2020). SLE was defined by ICD-10 (International Classification of Disease, 10th revision) code, M32. Incidence and prevalence per 100,000 person-years (PYs) were calculated and stratified by year and age. Results: Between 2011~2020, SLE incidence was 8.2 (95% confidence interval [CI] 8.1 to 8.4)/100,000 PYs, and prevalence 90.6 (95% CI 90.1 to 91.2)/100,000 PYs among women of childbearing age. Incidence remained similar between 2011~2015 and 2016~2020 (8.2 vs. 8.3/100,000 PYs, p=0.403), but prevalence was significantly increased in 2016~2020 compared to 2011~2015 (98.0 vs. 83.5/100,000 PYs, p<0.001). Age-stratified incidence showed a reverse J-shaped distribution, peaking at ages 20~24, then declining and stabilizing through 30~49 years. Age-stratified prevalence followed a bell-shaped curve, peaking at ages 40~44. This incidence pattern remained consistent between 2011~2015 and 2016~2020, but prevalence shifted left in 2016~2020, with a notable increase in the 45~49 age group. Conclusion: The prevalence of SLE among Korean women of childbearing age increased during 2016~2020 compared with 2011~2015, despite stable incidence. This rising prevalence may reflect improved survival associated with advances in disease management.
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