ArticleFrontiers in pediatrics2026
Non-linear associations between inflammatory biomarkers and
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: To characterize non-linear associations between inflammatory biomarkers and Methods: We retrospectively analyzed 319 children hospitalized for Results: LASSO regression identified three independent predictors: white blood cell (WBC) count, C-reactive protein (CRP), and fever duration. RCS analysis revealed a significant non-linear, threshold-like association for WBC ( Conclusions: WBC count, CRP, and fever duration independently predict MPNP, with WBC and CRP exhibiting distinct non-linear dose-response patterns. The RCS-based nomogram integrating these readily available predictors shows promising predictive performance, though external validation is required before clinical implementation.
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