SynthesisFrontiers in immunology2026
A systematic review and meta-analysis reveals enrichment of pro-inflammatory and bacterial immunity-modulating taxa in oral squamous cell carcinoma.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Oral squamous cell carcinoma (OSCC) is a major concern due to high recurrence, therapeutic resistance, and mortality. Increasing evidence indicates that oral microbiome dysbiosis contributes to OSCC development, yet comprehensive multi-cohort evaluations are limited. A systematic review and meta-analysis of the oral microbiome was conducted to identify conserved taxa in patients with OSCC. Methods: A systematic review and meta-analysis was conducted according to PRISMA guidelines, using data from PubMed, Embase, Web of Science, and Google Scholar. Raw 16S rDNA sequences were processed in QIIME 2 (v2024.10) for quality control, taxonomic classification, and diversity analysis. Linear Discriminant Analysis Effect Size (LEfSe) analyses and machine learning were used for the identification of conserved taxa. Results: Significant microbial shifts were observed between OSCC and healthy groups. OSCC samples showed enrichment of taxa, which further identified as conserved taxa such as Conclusion: Overall, this study demonstrates the enrichment of microbial taxa associated with chronic inflammation and carcinogenesis, along with a depletion of protective commensal microbes in patients with OSCC. These findings highlight distinct taxonomic and functional microbiome signatures associated with OSCC and emphasize the influence of sample type and geography on oral microbial composition. The enrichment of predicted inflammatory genes, transport-associated genes, and bacterial immune-related genes suggests the potential contribution of microbial communities to chronic inflammation and tumor progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.