ArticleFrontiers in endocrinology2026
Triglycerides and ovarian response in diminished ovarian reserve: a two-sample mendelian randomization and clinical mediation study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diminished ovarian reserve (DOR) impairs assisted reproduction. Whether triglyceride (TG) plays a causal role in ovarian reserve remains unclear. Methods: We performed a bidirectional two-sample Mendelian randomization (MR) analysis using female-specific GWAS data to assess causality between metabolic traits and ovarian reserve markers (AMH, FSH). Findings were validated in a retrospective cohort of 8,851 DOR women undergoing their first IVF/ICSI cycle, using mediation analysis to elucidate pathways to oocyte yield. Results: MR revealed that genetically predicted TG was causally associated with lower FSH (IVW β=-0.096, FDR = 5.28×10 Conclusion: This study provides genetic evidence for a causal role of TG in lowering FSH and identifies a suppression pathway through which TG affects oocyte yield. These findings provide additional insight into the relationship between lipid metabolism and ovarian reserve, and highlight TG as a potential modifiable factor worthy of further investigation.
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