Evidence map›Paper›PMID 42812251›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2026

Five years after introduction of an opt-out consent system for organ donation; lessons learned from England and the Netherlands.

Nichon Esther Jansen, Tineke Jentina Wind, Martin B A Heemskerk, Aline C Hemke, Claire Williment, Sue Madden, Dale Gardiner

Abstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nichon Esther JansenResearch Department, Dutch Transplant Foundation, Leiden, Netherlands.
Tineke Jentina WindDepartment of Organ Donation Coordination, Maastricht Universitair Medisch Centrum+, Maastricht, Netherlands.
Martin B A HeemskerkResearch Department, Dutch Transplant Foundation, Leiden, Netherlands.
Aline C HemkeResearch Department, Dutch Transplant Foundation, Leiden, Netherlands.
Claire WillimentNHS Blood and Transplant Blood Donation, Bristol, United Kingdom.
Sue MaddenNHS Blood and Transplant Blood Donation, Bristol, United Kingdom.
Dale GardinerNHS Blood and Transplant Blood Donation, Bristol, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Five years after changing from opt-in to opt-out consent systems in England and the Netherlands, we examine the impact on donor registrations, consent rates, donor numbers, and reflect on lessons learned. Opt-out legislation was implemented in May 2020 in England and July 2020 in the Netherlands. In England, 44% of the population is now registered; 40% recording an opt-in decision and 4% an opt-out decision. In the Netherlands, mandated donor registration resulted in the entire adult population having their decision recorded: "Yes, I want to be a donor" (34%), "No objection" (24%), or "No, I don't want to be a donor" (31%), while 11% leave the "Decision to next of kin". Despite these structural changes, the consent categories created by opt-out legislation ("deemed" consent in England and "No objection" in the Netherlands) remain challenging in practice, with fewer than 50% of families agreeing to donation. In England, the family consent rate declined from 69% to 57% between 2020 and 2025 and the donor numbers remain below pre-pandemic levels. In contrast, the Netherlands experienced a modest increase in family consent rates and donor numbers compared to the opt-in consent system. Opt-out legislation provides an important policy framework, but sustained system-level commitment remains essential.

Indexed as

Informed ConsentTissue and Organ ProcurementTissue DonorsEnglandHumansNetherlandsdonor registerEngland and Netherlandslessons learnedopt-out consent systemorgan donation policy

Identifiers

PMID42812251
PMCPMC13619534

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Registered trials

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