ArticleNanotheranostics2026
Developing oxidative stress-responsive neuroprotective nanotheranostic agents for the image-guided treatment of radiotherapy-induced brain injury.
Article in Nanotheranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Rationale: Radiotherapy-induced brain injury (RIBI) is a chronic side effect, that affects up to ~90% of brain tumor survivors treated with radiotherapy. Chronic oxidative stress and neuroinflammation are key drivers of RIBI. Here, we developed oxidative stress-responsive polymeric nanotheranostic agents and evaluated their ability to reduce neuroinflammation in a preclinical mouse model of RIBI. Method: Two oxidative stress-responsive amphiphilic block copolymers possessing varied numbers of phenylboronic acid pinacol ester (BAPE) moieties to scavenge reactive oxygen species (ROS) were designed, synthesized, and characterized by proton and carbon-13 nuclear magnetic resonance spectroscopy. Polymer P2b was designed to have twice as many BAPE moieties as polymer P2a, for a structure-activity relationship study. The polymers were then formulated into nanoparticles and characterized using fluorescence spectroscopy, dynamic light-scattering, transmission and scanning electron microscopy, and fluorescence imaging. The ability of the agents to prevent the degradation of fluorescent R-phycoerythrin (RPE) protein under oxidative stress was also evaluated. Then, the cellular uptake and toxicity of the agents were evaluated in human umbilical vein endothelial cells (HUVECs). Next, the Results: Both polymers readily formed spherical nanoparticular micelles in aqueous milieu at low concentrations (~ 0.08 mg/mL), with comparable hydrodynamic diameters and zeta-potentials of 166 ± 51 nm and Conclusion: Collectively, these results showed that although both nanotheranostic agent P2a and P2b significantly reduced radiation-induced neuroinflammation, nanotheranostic agent P2b (with twice as many ROS scavengers) was more effective at reducing radiation-induced neuroinflammation in the preclinical mouse model of RIBI.
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