ArticleFrontiers in immunology2026
Impaired antigen clearance of macrophages associates with heart failure and non-obstructive azoospermia: insights from transcriptomics, in silico knockout, and
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Heart failure (HF) and non-obstructive azoospermia (NOA) are high-burden diseases that share chronic inflammation and tissue injury. Macrophages are key regulators in both conditions, yet whether a common molecular basis exists remains unclear. Methods: We analyzed HF and NOA expression profiles from the GEO database using WGCNA and machine learning to screen for core shared genes. Diagnostic performance was evaluated using AUC in independent validation sets. Single-cell RNA-seq mapped the cellular origin of core genes. Immune infiltration, pathway activity, and transcription factor networks were analyzed using xCell, PROGENy, and DoRothEA. To investigate functional roles, we applied single-cell in silico knockout to macrophages and designed Results: Conclusion:
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