Evidence map›Paper›PMID 42812144›Full record

ArticlebioRxiv : the preprint server for biology2026

Impact of cathelicidin cleavage by SpeB on

Stephanie Guerra, Claire Qu, Christopher N LaRock

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephanie GuerraDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Claire QuDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Christopher N LaRockDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.

Funding

Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
Proteolytic regulation of the Streptococcus pyogenes cell surfaceR01AI153071 · NIAID · EMORY UNIVERSITY · PI LAROCK, CHRISTOPHER N · 2021 to 2025
$1.9M
GSDMA roles in skin innate immune defenseR01AI180089 · NIAID · EMORY UNIVERSITY · PI Christopher N LaRock · 2024 to 2026
$1.8M
Investigating CovRS activation within skin microenvironments to drive heterogenicity of Streptococcus pyogenes gene expressionF31AI179103 · NIAID · EMORY UNIVERSITY · PI GUERRA, STEPHANIE CORINNE · 2023 to 2025
$146k
NIAID NIH HHS F31 AI179103NIAID NIH HHS R01 AI153071NIAID NIH HHS R01 AI180089NIAID NIH HHS T32 AI106699
6 · The paper itself

Abstract

Cathelicidins are a class of antimicrobial peptides (AMPs) that are part of the first line of defense of the innate immune system. While cathelicidin-derived peptides such as LL-37 can be directly bactericidal,

Indexed as

antimicrobial peptidecathelicidingene regulationinvasive infectionLL-37proteaseStreptococcus pyogenesvirulence factor

Identifiers

PMID42812144
PMCPMC13618651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.