ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
objectivesTo investigate the mechanism of
methodsThirty-two SD rats were randomized into normal control group, CIA model group, tripterygium glycosides (40 mg/kg; positive control) treatment group, and SX (40 g/kg) treatment group (
resultsSX treatment significantly alleviated joint swelling, lowered arthritis scores, improved synovial lesions, and reduced serum levels of TNF-α, IL-1β and IL-6 in CIA rats, resulting in also inhibition of macrophage polarization and down-regulation of HIF-1α, PDK1 and HK2 expressions in the synovial tissues. Twenty-nine components of SX were detected in the blood of SX-treated rats, and 9 key target genes were identified. AlphaFold3 predicted a strong interaction between HIF-1α and PDK1, and their virtual knockout was shown to disturb the inflammatory pathways in the macrophages. Molecular docking studies suggested stable docking between the active components of SX and their key targets.
conclusionsSX alleviates joint inflammation in CIA rats by inhibiting the HIF-1α/PDK1 signaling pathway, correcting glycolytic reprogramming, and promoting M2 polarization of macrophages.
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