ArticleClinical physiology and functional imaging2026
Diffusely impaired myocardial perfusion in patients with suspected coronary artery disease: Clinical utility of relative perfusion.
Article in Clinical physiology and functional imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIn patients with suspected coronary artery disease (CAD), diffusely impaired hyperaemic myocardial blood flow (MBF) may indicate a multivessel epicardial CAD but also impaired coronary microcirculation. We assessed whether relative hyperaemic MBF-that is, the ratio of the lowest to the highest regional hyperaemic MBF-predicts obstructive CAD in patients with diffusely impaired hyperaemic MBF.
methodsWe studied 874 patients who underwent coronary computed tomography angiography and [
resultsIn ICA, 34/64 (53%) patients had obstructive CAD. Compared to patients with non-obstructive CAD, those with obstructive CAD had lower relative hyperaemic MBF: 66% (95% CI 62-69%) versus 52% (95% CI 47-57%), respectively (p < 0.001). When relative hyperaemic MBF was used to predict the presence of obstructive CAD in ICA, the receiver operating characteristic analysis showed an area under the curve of 0.778 (95% CI 0.666-0.891). In binary logistic regression analysis, relative hyperaemic MBF independently predicted obstructive CAD (OR = 0.92 [95% CI 0.86-0.97], p = 0.004).
conclusionObstructive CAD is more likely in patients with lower relative hyperaemic MBF. Consequently, relative hyperaemic MBF may have clinical utility in patients with suspected CAD and diffusely impaired hyperaemic MBF.
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