SynthesisTransboundary and emerging diseases2026
Systematic Review and Meta-Analysis of Emerging Viral Zoonotic Diseases, 2016-2026.
Synthesis in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review and Meta-Analysis of Emerging Viral Zoonotic Diseases, 2016-2026.Transboundary and emerging diseases · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Emerging viral zoonoses-infections caused by viruses that cross the species barrier from animal reservoirs into human populations-account for the majority of emerging infectious disease (EID) events and now constitute a defining threat to global health security. Over the past decade the tempo of these spillovers has increased, propelled by land-use change, agricultural intensification, wildlife trade, and climate change, while reverse zoonosis-the transmission of human pathogens back into animal populations-has created novel animal reservoirs capable of seeding future outbreaks. Against this backdrop, we systematically reviewed and meta-analyzed epidemiological evidence on emerging viral zoonoses from January 2016 through June 2026, searching five bibliographic databases and synthesizing 312 included studies. Annual high-consequence spillover events increased by 4.98% (95% CI 3.22%-6.76%), and the decade saw five Public Health Emergency of International Concern (PHEIC) declarations, alongside other high-consequence spillovers such as the 2026 Bundibugyo virus outbreak (case fatality rate [CFR] 30.9%) and the expansion of H5N1 highly pathogenic avian influenza into dairy cattle. Bat-origin viruses exhibited the highest pooled CFR (29.86%), whereas primate-origin viruses demonstrated greater transmissibility, supporting a virulence-transmissibility trade-off. Land-use change emerged as the dominant anthropogenic driver, increasing zoonotic host diversity by 18%-72%. White-tailed deer SARS-CoV-2 seroprevalence reached 32.7% (95% CI 21.4%-46.1%), with confirmed deer-to-human spillback. Nonpharmaceutical interventions (NPIs) collectively reduced the effective reproduction number by up to 82%, and prevention-oriented One Health strategies yielded returns exceeding 1100% on investment. Viral zoonoses are accelerating under anthropogenic pressure, and upstream prevention with integrated One Health surveillance represents the most cost-effective pandemic preparedness strategy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.