Evidence map›Paper›PMID 42811476›Full record

ArticleEmerging infectious diseases2026

Baloxavir-Based Combination Therapy for Protection against Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Mice.

Seong Cheol Min, Ju Ryeong Lee, Beom Kyu Kim, Ji-Hyun Park, Dong Gyu Lee, Gi Chan Lee, Se Hee An, Santosh Chokkakula, Aman Jain, Young Ki Choi and 2 more

Abstract read
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In one paragraph

Article in Emerging infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Seong Cheol Min
Ju Ryeong Lee
Beom Kyu Kim
Ji-Hyun Park
Dong Gyu Lee
Gi Chan Lee
Se Hee An
Santosh Chokkakula
Aman Jain
Young Ki Choi
Yun Hee Baek
Min-Suk Song

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus continues to cause animal outbreaks and sporadic zoonotic infections. In a mouse model of lethal influenza disease, we compared oseltamivir, baloxavir, and molnupiravir monotherapies with 2-drug combinations. Baloxavir-based combinations improved survival, reduced lung viral loads, and prevented extrapulmonary dissemination, supporting H5N1 preparedness strategies.

Indexed as

Antiviral AgentsInfluenza A Virus, H5N1 SubtypeOrthomyxoviridae InfectionsOxazinesPyridinesThiepinsTriazinesAcids, CarbocyclicAnimalsDibenzothiepinsDisease Models, AnimalDrug Therapy, CombinationFemaleHumansLungMiceAcids, CarbocyclicAntiviral AgentsbaloxavirDibenzothiepinsMorpholinesOseltamivirOxazinesPhthalazinesPyridinesPyridonesThiepinsTriazinesbaloxavirdrug combinationsH5N1 subtypeInfluenzainfluenza A virusmolnupiraviroseltamivirrespiratory infectionsviruseszoonoses

Identifiers

PMID42811476
PMCPMC13632834

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.