ArticleHealth and quality of life outcomes2026
Economic toxicity and quality of life in stroke patients: a moderated mediation model of self-management and family function.
Article in Health and quality of life outcomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the relationships among economic toxicity, family function, self-management ability, and stroke-specific quality of life in stroke patients during the rehabilitation period, and to construct and test a moderated mediation model with self-management as the mediator and family function as the moderator, so as to provide empirical evidence for improving the quality of life of stroke patients.
methodsA cross-sectional survey was conducted from May to June 2025 across 22 medical and elderly care institutions in Chongqing, China. A total of 557 stroke patients in the rehabilitation period completed questionnaires measuring sociodemographics, economic toxicity (COST-PROM), family function (Family APGAR Scale), self-management (Stroke Self-Management Scale), and stroke-specific QoL (SS-QOL Scale). The moderated mediation model was tested using the PROCESS macro in SAS 9.4.
resultsEconomic toxicity was significantly negatively correlated with quality of life (r = -0.424, P < 0.001); self-management played a partial mediating role between economic toxicity and quality of life, with the mediating effect accounting for 50.56%; family function played a significant buffering moderating role between economic toxicity and self-management (β = 0.209, P < 0.001), and high family function could significantly weaken the negative impact of economic toxicity on self-management.
conclusionEconomic toxicity impairs QoL both directly and indirectly through reduced self-management. Strong family function buffers the detrimental effect of economic toxicity on self-management. Interventions targeting economic toxicity screening, self-management support, and family empowerment may help improve QoL in stroke survivors and warrant prospective evaluation.
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