ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026
[Mechanisms of live combined
Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the ameliorative effects of live combined
methodsRats were randomly divided into blank control, LCBLE control, model control, and LCBLE treatment groups. Rats in the LCBLE control and LCBLE treatment groups were administered LCBLE by gavage for 7 consecutive days prior to heat stroke modeling, while those in the blank control and model control groups received an equal volume of physiological saline. On day 8, heat stroke was induced in the model control and LCBLE treatment groups. Core body temperature, body weight and survival rate were monitored. Serum levels of inflammatory factors and intestinal fatty acid-binding protein (I-FABP) were measured by enzyme-linked immunosorbent assay;
resultsCompared with the model control group, LCBLE treatment significantly reduced peak core body temperature [(43.21±0.33) ℃
conclusionsProphylactic administration of LCBLE improves heat tolerance and alleviates systemic inflammatory injury in heat stroke rats, likely through maintaining intestinal barrier integrity and regulating gut microbiota.
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