Evidence map›Paper›PMID 42811256›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026

[Mechanism of Huangqin Qingre Chubi Capsule in inhibiting inflammation and proliferation of fibroblast-like synoviocyte in rheumatoid arthritis].

Yuedi Hu, Jian Liu

Abstract readEnglish Abstract
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yuedi HuDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China. yuedihu@foxmail.com.
Jian LiuDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China. liujianahzy@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo clarify the role of the ALKBH5

methodsDifferentially expressed genes (DEGs) between RA patients and healthy individuals were screened based on microarray datasets from the Gene Expression Omnibus (GEO) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to identify related biological processes and pathways. A co-culture model of peripheral blood mononuclear cells and RA-FLS was established. Through overexpression or silencing of

results

conclusionsHQC inhibits inflammation and proliferation of RA-FLS by targeting eIF4A3 through ALKBH5-mediated m⁶A modification of circ_0091685.

Indexed as

Arthritis, RheumatoidDrugs, Chinese HerbalSynoviocytesAlkB Homolog 5, RNA DemethylaseAnimalsCell ProliferationCells, CulturedEukaryotic Initiation Factor-4AFibroblastsHumansInflammationMaleRatsRNA, CircularAlkB Homolog 5, RNA DemethylaseDrugs, Chinese HerbalEukaryotic Initiation Factor-4ARNA, CircularALKBH5circ_0091685eIF4A3Fibroblast-like synoviocyteHuangqin Qingre Chubi CapsuleInflammationMethylation modificationProliferationRatsRheumatoid arthritis

Identifiers

PMID42811256
PMCPMC13652677

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.