Evidence map›Paper›PMID 42811197›Full record

ArticleProbiotics and antimicrobial proteins2026

Lactobacillus and Tryptophan Supplementation Improve Renal Function and are Associated with Metabolomic Alterations in a Mouse Model of Chronic Kidney Disease.

Miaoyu Yin, Mengdi Li, Yan Zhang, Bingxiao Wang, Guanhua Li, Ge Wu

Abstract read
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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Miaoyu YinDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Mengdi LiDepartment of Nephrology, Ninth People's Hospital of Zhengzhou, Zhengzhou, 450053, China.
Yan ZhangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Bingxiao WangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Guanhua LiDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Ge WuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. fccwug@zzu.edu.cn.

Funding

2022 Leading Talents of Henan Provincial Health Department YXKC20220182026 Henan Province Key Scientific Research Project Plan for Higher Education Institutions 26A320062National Natural Science Foundation of China 82001732
6 · The paper itself

Abstract

Gut microbiota has been implicated in chronic kidney disease (CKD) progression. Probiotics such as Lactobacillus may alleviate renal injury through metabolic modulation, whereas tryptophan metabolism may have divergent effects in CKD. However, whether Lactobacillus and tryptophan supplementation are associated with distinct or overlapping metabolic profiles in CKD remains unclear. This study aimed to evaluate the effects of Lactobacillus and tryptophan supplementation and characterize the associated serum and fecal metabolomic alterations in an adenine-induced CKD mouse model. Six-week-old male mice were fed adenine for 3 weeks to induce CKD, followed by 8 weeks of treatment: saline for control (NC, CKD), Lactobacillus (2 × 10

Indexed as

Chronic kidney diseaseGut microbiotaLactobacillusMetabolomicsTryptophan

Identifiers

PMID42811197

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.