Evidence map›Paper›PMID 42811194›Full record

ArticleEJNMMI research2026

TSPO PET selectively detects the denervated skeletal muscle district remodeling after experimental peripheral nerve injury.

Serena Losacco, Irene Di Patrizi, Edoardo Dighero, Maddalena Ghelardoni, Mattia Riondato, Roberta Resaz, Laura Emionite, Sabrina Chiesa, Matteo Bauckneht, Mattia Camera and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Serena LosaccoDepartment of Health Sciences, University of Genoa, 16132, Genoa, Italy.
Irene Di PatriziRadiology Unit, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Edoardo DigheroDepartment of Health Sciences, University of Genoa, 16132, Genoa, Italy.
Maddalena GhelardoniNuclear Medicine, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Mattia RiondatoNuclear Medicine, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Roberta ResazAnimal Facility, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Laura EmioniteAnimal Facility, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Sabrina ChiesaNuclear Medicine, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Matteo BaucknehtDepartment of Health Sciences, University of Genoa, 16132, Genoa, Italy.
Mattia CameraUO Clinica Neurologica, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Giovanna CapodiventoUO Clinica Neurologica, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Francesca VitaleNuclear Medicine, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Sonia CartaNuclear Medicine, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Luca SofiaDepartment of Health Sciences, University of Genoa, 16132, Genoa, Italy.
Roberta PivaNuclear Medicine, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Anna Maria OrengoNuclear Medicine, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Mehrnaz HamedaniDINOGMI, University of Genoa, 16132, Genoa, Italy.
Federico ZaottiniDepartment of Health Sciences, University of Genoa, 16132, Genoa, Italy.
Carlo MartinoliDepartment of Health Sciences, University of Genoa, 16132, Genoa, Italy.
Lucilla NobbioUO Clinica Neurologica, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Angelo SchenoneUO Clinica Neurologica, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Gianmario SambucetiDepartment of Health Sciences, University of Genoa, 16132, Genoa, Italy.
Cecilia MariniNuclear Medicine, AOM - IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy. Cecilia.Marini@cnr.it.ORCID http://orcid.org/0000-0003-1682-578X

Funding

Ministero della Salute RF-2021-12372711Ministero della Salute T4-AN-10Ministero dell'Istruzione, dell'Università e della Ricerca PE0000006
6 · The paper itself

Abstract

backgroundPeripheral nerve injury induces inflammatory and stress-related remodeling in downstream skeletal muscle before overt atrophy develops, yet non-invasive approaches capable of detecting and anatomically localizing early muscle involvement remain limited. The 18-kDa translocator protein (TSPO), a marker of inflammatory activation and mitochondrial stress, is a molecular target for PET imaging with [

resultsAdult mice underwent unilateral sciatic nerve crush. One-week post-injury, static [

conclusionsTSPO-targeted PET with [

Indexed as

[18F]DPA-714Peripheral nerve injuryPETSciatic nerve crushSkeletal muscleTSPO

Identifiers

PMID42811194
PMCPMC13624233

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.