Mechanical regulation of cell memory.

Yifan Wu, Fazlur Rashid, Luay Almassalha, Vadim Backman, Ning Wang, Song Li

Abstract readReview

In one paragraph

Review in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yifan Wu *Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0009-0537-5518

Fazlur Rashid *Institute for Mechanobiology, Department of Bioengineering, College of Engineering, Northeastern University, Boston, MA, USA.

Luay AlmassalhaDivision of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Vadim BackmanDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA. v-backman@northwestern.edu.ORCID http://orcid.org/0000-0003-1981-1818

Ning WangInstitute for Mechanobiology, Department of Bioengineering, College of Engineering, Northeastern University, Boston, MA, USA. ni.wang@northeastern.edu.ORCID http://orcid.org/0000-0001-7531-7385

Song LiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA. songli@ucla.edu.ORCID http://orcid.org/0000-0002-4760-8828

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell memory describes the capacity of a cell to retain induced biological changes following withdrawal of initiating signals. Accumulating evidence reveals that mechanical stimuli in the microenvironment not only drive immediate structural reorganization in cells and extracellular matrix (ECM), but also can induce long-term changes in cell phenotype and identity. These effects underlie critical biological phenomena, including cell migration, differentiation and reprogramming. In this Review, we present an integrative framework for understanding how mechanical signals modulate cellular structure, identity and function in the context of cell memory. We examine how external forces and the mechanical properties of the ECM reconfigure the structural memory of mechanosensitive molecules, spatial distribution of transcription factors and ECM organization. We offer insights on the mechanical regulation of epigenetic memory, highlighting both mechano-chemical pathways and direct mechanical influences on nuclear architecture.

Identifiers

PMID42811182

DOI10.1038/s41551-021-00709-w

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.