Evidence map›Paper›PMID 42811174›Full record

ArticleJournal of general internal medicine2026

Racial and Ethnic Disparities in Buprenorphine and Naloxone among Medicaid Beneficiaries after Emergency Department Visits and Hospitalizations.

Hazar Khidir, Laurence Nedelec, Stefanie S Sebok-Syer, Amber K Sabbatini, Ikgyu Shin, Edward R Melnick, Michelle P Lin

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Article in Journal of general internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Hazar KhidirEmergency Medicine, Henry Ford Hospital, Detroit, MI, USA.
Laurence NedelecEmergency Medicine, Stanford University, Palo Alto, CA, USA.
Stefanie S Sebok-SyerEmergency Medicine, Indiana University, IN, Indianapolis, USA.
Amber K SabbatiniEmergency Medicine, University of Washington, Seattle, WA, USA.
Ikgyu ShinBiomedical Informatics & Data Science, Yale University, New Haven, CT, USA.
Edward R MelnickEmergency Medicine, Yale University, New Haven, CT, USA.
Michelle P LinEmergency Medicine, Stanford University, Palo Alto, CA, USA. mplin@stanford.edu.ORCID http://orcid.org/0000-0001-6045-7342

Funding

EMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use DisorderUH3DA047003 · NIDA · YALE UNIVERSITY · PI D'ONOFRIO, GAIL, MELNICK, EDWARD ROBERT · 2019 to 2022
$7.2M
NIDA NIH HHS UH3DA047003
6 · The paper itself

Abstract

backgroundED visits and hospitalizations for opioid use disorder (OUD) are key opportunities to prescribe buprenorphine and naloxone, and Medicaid is the dominant payer for individuals with OUD. Our objective was to examine racial and ethnic disparities in buprenorphine and naloxone receipt and buprenorphine retention after acute opioid-related encounters among Medicaid beneficiaries.

methodsRetrospective cohort study of beneficiaries aged 18-64 years in 19 states using 100% Medicaid 2016-2019 claims. Eligible encounters had a nonfatal emergency department, acute inpatient, or inpatient rehab/detox encounter for opioid overdose, withdrawal, or injection drug use-related infection. Primary outcomes were buprenorphine and naloxone prescription fills within 30 days. Secondary outcomes were fills within 3 days and buprenorphine retention (≥ 150 days' supply within 180 days). Hierarchical logistic regression adjusted for demographics, comorbidities, prior treatment, diagnosis, state, and year.

resultsThere were 234,944 events among 169,721 beneficiaries. Mean age was 37.48 years, 43.36% were female, 68.1% were White, 11.5% were Black, and 11.1% were Hispanic. Across all events, 14.08% filled buprenorphine and 3.78% filled naloxone within 30 days, and 4.62% were retained on buprenorphine at 180 days. Compared with non-Hispanic White patients, adjusted odds of 30-day buprenorphine fills were lower for Black (ED: aOR 0.79, 95% CI 0.71-0.88, inpatient: aOR 0.72, 0.63-0.83, rehab/detox: aOR 0.83, 0.71-0.97) and Hispanic patients (ED: aOR 0.80, 0.73-0.88, inpatient: aOR 0.83, 0.75-0.93). Buprenorphine retention was lower for Black (ED: aOR 0.64, 0.55-0.74, inpatient: aOR 0.51, 0.43-0.60, rehab/detox: OR a0.63, 0.48-0.82) and Hispanic (ED: aOR 0.70, 0.62-0.79, inpatient: aOR 0.66, 0.56-0.78) patients.

conclusionsIn this multi-state Medicaid cohort, Black and Hispanic beneficiaries had consistently lower buprenorphine receipt and retention across acute care settings. Improved transitional care and targeted Medicaid reforms may promote timely and equitable access to OUD treatment.

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PMID42811174

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