ArticleEye (London, England)2026
Effects of narrow macular staphyloma, male sex and younger age on the risk of lacquer cracks in patients with high myopia.
Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLacquer cracks (LCs) are linear breaks in Bruch's membrane in highly myopic eyes; however, their risk factors remain fully unclarified. We determined associations between age, staphyloma type and LC risk in highly myopic eyes.
methodsThis retrospective study reviewed 226 eyes of 141 patients with high myopia (refractive error < -8 dioptres or axial length ≥26.5 mm), including 64 eyes with LCs and 162 eyes without LCs.
resultsMale sex (odds ratio [OR] = 2.962, 95% confidence interval [CI]: 1.343-6.533), higher myopia (refractive error < -12.25 dioptres [a median refractive error in all eyes]) (OR = 7.029, 95% CI: 2.957-16.708) and narrow macular staphyloma (OR = 3.212, 95% CI: 1.048-9.844) were associated with increased risk of LCs, while older age (OR = 0.941, 95% CI: 0.893-0.992) was associated with decreased risk of LCs. Narrow macular staphyloma-related LC risk was observed in the younger age subgroup (OR = 5.354, 95% CI: 0.948-30.244) but not observed in the older age subgroup (OR = 1.837, 95% CI: 0.371-9.084). Male sex-related LC risk was observed in the older age subgroup (OR = 6.929, 95% CI: 2.085-23.024) but not observed in the younger age subgroup (OR = 1.671, 95% CI: 0.558-5.005).
conclusionNarrow macular staphyloma, male sex and younger age are predictors of LCs in patients with high myopia. Younger age with narrow macular staphyloma or older age with male sex showed synergistic effects on LC risk. This suggests that these high-risk patients require regular monitoring and frequent ophthalmic evaluations to ensure a good prognosis.
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