Evidence map›Paper›PMID 42811076›Full record

ArticleNature genetics2026

CCNB1IP1 regulatory evolution underlies gradual increases in cortical size and folding in primates.

Ting Hu, Pengcheng Ma, Yifan Kong, Yulian Tan, Xuelian Sun, Jianhong Wang, Kun Xiang, Bingyu Mao, Qingfeng Wu, Soojin V Yi and 1 more

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Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ting Hu *State Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China.
Pengcheng Ma *State Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China.ORCID http://orcid.org/0000-0002-1067-8021
Yifan Kong *State Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China.
Yulian Tan *State Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China.
Xuelian SunState Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Jianhong WangState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China.
Kun XiangThe First People's Hospital of Yunnan Province, Kunming, People's Republic of China.
Bingyu MaoState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China.ORCID http://orcid.org/0000-0002-7993-3158
Qingfeng WuState Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China.ORCID http://orcid.org/0000-0003-3272-6247
Soojin V YiDepartment of Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0003-1497-1871
Lei ShiState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China. shilei@mail.kiz.ac.cn.ORCID http://orcid.org/0000-0003-3583-4649

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gradual expansion and folding of the cortex are key factors in human cognitive evolution, yet their molecular underpinnings remain not well understood. Here we identify cyclin B1 interacting protein 1 (CCNB1IP1) gene as a key regulator of human brain evolution using tree shrew as an outgroup. In primates, CCNB1IP1 acquired brain expression and gradually increased its expression during evolution, mirroring the increase of cortical size and folding. Comparative analysis of cis-regulatory elements reveals evolutionary changes underlying the increase of CCNB1IP1 expression. Overexpression of CCNB1IP1 affects the cell cycle, increasing the abundance of basal progenitors and neurons. Mechanistically, we demonstrated that CCNB1IP1 represses the transcription factor E2F1 through the ubiquitin-mediated degradation pathway. Moreover, CCNB1IP1 knock-in can develop cortical folding in otherwise smooth mouse brains. These findings reveal that evolutionary changes in CCNB1IP1 expression have contributed to the enlargement and folding of the primate cortex.

Indexed as

Cerebral CortexEvolution, MolecularPrimatesAnimalsCell CycleHumansMiceNeurons

Identifiers

PMID42811076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.