ReviewCommunications chemistry2026
Progress and challenges in traceless ligand-directed labelling chemistry.
Review in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traceless ligand-directed labelling (t-LDL) of proteins is emerging as a potential strategy for addressing the challenge of studying biology within native cellular contexts. By exploiting proximity-driven reactivity, t-LDL enables the selective transfer of small functional groups to residues distal to canonical binding or active sites, allowing the delivery ligand to dissociate following labelling. This review summarises the development of t-LDL chemistry, with a focus on transfer and catalyst-tethered approaches. It highlights key recent advances that expand the mechanistic and functional scope of t-LDL alongside outstanding challenges and opportunities for further development. Examples of applications in live-cell imaging, proteomics, proximity-induced post-translational modification and signalling rewiring, showcase the growing opportunities of this labelling technology.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.