Evidence map›Paper›PMID 42811040›Full record

Trial reportNature communications2026

Multidisciplinary intervention in frail elderly patients with cardiovascular diseases: a multicentre, single-blinded, randomised controlled trial.

Ke Chai, Chen Meng, Liwei Ji, Yujia Liu, Zhao Ma, Linlin Qiao, Lijuan Wang, Di Guo, Ning Sun, Lingling Cui and 11 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ke Chai *Department of Cardiology, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.ORCID 0000-0002-5869-9083
Chen Meng *Department of Geriatric Medicine, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Liwei JiDepartment of Pharmacy, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Yujia LiuDepartment of Cardiology, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Zhao MaDepartment of Rehabilitation Medicine, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Linlin QiaoDepartment of Traditional Chinese Medicine, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Lijuan WangDepartment of Nutrition, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Di GuoDepartment of Cardiology, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Ning SunDepartment of Cardiology, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Lingling CuiDepartment of Cardiology, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Simin YaoDepartment of Cardiology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Peipei ZhengDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xuelu ZhuDepartment of Biostatistics, Clinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, China.ORCID 0009-0007-3328-7211
Wei DongSenior Department of Cardiology, The Sixth Medical Centre of PLA General Hospital, Beijing, China.
Ping ZengThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, National Centre for Gerontology, Beijing, China.
Yao LuClinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, China.
Ping ZhangBeijing Tsinghua Changgung Hospital, Beijing, China.
Guobin MiaoDepartment of Emergency, Emergency General Hospital, Beijing, China.
Yi LiDepartment of Traditional Chinese Medicine, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. liyi_doc@163.com.ORCID 0000-0002-0511-2808
Jiefu YangDepartment of Cardiology, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. yangjiefu2011@126.com.ORCID 0000-0002-2273-4860
Hua WangDepartment of Cardiology, Beijing Hospital, National Centre for Gerontology; National Clinical Research Centre for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. wh74220@aliyun.com.ORCID 0000-0002-1643-4108

Funding

Beijing Municipal Science and Technology Commission D181100000218003
6 · The paper itself

Abstract

Evidence supporting multidisciplinary interventions for frailty in elderly cardiovascular inpatients remains limited. In this completed multicentre, single-blinded, randomised controlled trial (ChiCTR1900022623), 333 frail inpatients aged ≥ 70 years with cardiovascular diseases were randomly assigned to RENAP (Rehabilitation exercises, patient Education, Nutritional guidance, Acupoint massage, and Polypharmacy management) programme (n = 166) or usual care (n = 167). The trial was supported by grants from the Beijing Municipal Science and Technology Commission and the Chinese Academy of Medical Sciences. The primary outcomes were changes from baseline to 12 months in Fried Frailty Phenotype (FFP) and Short Physical Performance Battery (SPPB) scores at one year. RENAP significantly improved FFP score [t(993) = -4.79; P < 0.001; adjusted mean difference -0.79; 95% CI: -1.11 to -0.46] and SPPB score [t(993) = 4.06; P < 0.001; adjusted mean difference 2.02; 95% CI: 1.04 to 2.99]. No treatment-related serious adverse events were observed during the study. These findings suggest that a hospital-initiated multidisciplinary programme may improve frailty and physical function in frail elderly adults with cardiovascular diseases. The single-city setting and loss to follow-up may limit generalisability and warrant confirmation in broader healthcare settings.

Indexed as

Cardiovascular DiseasesFrail ElderlyFrailtyAgedAged, 80 and overExercise TherapyFemaleHumansMalePatient Education as TopicSingle-Blind MethodTreatment Outcome

Identifiers

PMID42811040
PMCPMC13623951

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.