Evidence map›Paper›PMID 42811027›Full record

ArticleNature communications2026

Single-cell landscape of human liver sinusoidal γδ T cells in the context of latent human cytomegalovirus infection.

Dong-Uk Kim, Bae-Hyeon Moon, Young-Jun Kim, Saerom Kweon, Hye Jung Park, Jae Geun Lee, Deok-Gie Kim, Eun-Ki Min, Myoung Soo Kim, Su-Hyung Park and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dong-Uk Kim *Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID 0000-0003-3908-8698
Bae-Hyeon Moon *Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID 0000-0002-2602-7389
Young-Jun Kim *Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID 0009-0001-9519-6207
Saerom KweonGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID 0009-0004-0192-7622
Hye Jung ParkDepartment of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea.
Jae Geun LeeDepartment of Surgery and the Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0002-6722-0257
Deok-Gie KimDepartment of Surgery and the Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea.
Eun-Ki MinDepartment of Surgery and the Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea.
Myoung Soo KimDepartment of Surgery and the Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea.
Su-Hyung ParkGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID 0000-0001-6363-7736
Jun Yong ParkDepartment of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea. drpjy@yuhs.ac.ORCID 0000-0001-6324-2224
Dong Jin JooDepartment of Surgery and the Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea. djjoo@yuhs.ac.ORCID 0000-0001-8405-1531
Eui-Cheol ShinGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. ecshin@kaist.ac.kr.ORCID 0000-0002-6308-9503

Funding

Korea Health Industry Development Institute (KHIDI) RS-2025-25460003Ministry of Food and Drug Safety (MFDS) RS-2025-02213409National Research Foundation of Korea (NRF) RS-2024-00439160
6 · The paper itself

Abstract

Human γδ T cells are typically divided into Vγ9Vδ2 and non-Vγ9Vδ2 cells, but their detailed heterogeneity remains to be fully elucidated, especially in the liver where they are enriched. Here we analyze liver sinusoidal γδ T cells from healthy donors, with or without latent human cytomegalovirus (HCMV) infection, by performing single-cell RNA sequencing with antibody-derived tags. Vγ9Vδ2 cells are characterized by PLZF expression, and classified into type 1 and type 3 immunity-associated clusters. In contrast, non-Vγ9Vδ2 cells are characterized by Helios expression, and their clusters display naïve-to-effector differentiation processes, which are accelerated by HCMV infection. Notably, among non-Vγ9Vδ2 cells, we identify a novel liver-resident CD56

Indexed as

CytomegalovirusCytomegalovirus InfectionsLiverReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesCD56 AntigenHumansInterleukin-15Promyelocytic Leukemia Zinc Finger ProteinSingle-Cell AnalysisVirus LatencyCD56 AntigenInterleukin-15Promyelocytic Leukemia Zinc Finger ProteinReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID42811027
PMCPMC13623833

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.