Evidence map›Paper›PMID 42810102›Full record

ArticleNeuroImage. Clinical2026

Why are you looking at me like that? Intolerance of uncertainty and emotional face processing in social anxiety disorder.

Antonia Küttner, Esther Zwiky, Philine König, Konrad Schöniger, Robin Kamrla, Gina Sophie Scheiwe, Julia Andreev, Johanna Elea Hamann, Annika Brückner, Sina Pletsch and 5 more

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Article in NeuroImage. Clinical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Antonia KüttnerDepartment of Psychology, University of Halle, Germany. Electronic address: antonia.kuettner@psych.uni-halle.de.
Esther ZwikyDepartment of Psychology, University of Halle, Germany; German Center for Mental Health (DZPG), Halle-Jena-Magdeburg, Germany.
Philine KönigDepartment of Psychology, University of Halle, Germany.
Konrad SchönigerDepartment of Psychology, University of Halle, Germany; German Center for Mental Health (DZPG), Halle-Jena-Magdeburg, Germany.
Robin KamrlaDepartment of Psychology, University of Halle, Germany; German Center for Mental Health (DZPG), Halle-Jena-Magdeburg, Germany.
Gina Sophie ScheiweDepartment of Psychology, University of Halle, Germany.
Julia AndreevDepartment of Psychology, University of Halle, Germany.
Johanna Elea HamannDepartment of Psychology, University of Halle, Germany.
Annika BrücknerDepartment of Psychology, University of Halle, Germany.
Sina PletschDepartment of Psychology, University of Halle, Germany.
Janine SelleDepartment of Psychology, University of Halle, Germany; German Center for Mental Health (DZPG), Halle-Jena-Magdeburg, Germany; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg, Germany.
Alexander GussewUniversity Clinic and Policlinic for Radiology, University Hospital Halle, University Medicine Halle, Germany; Halle MR Imaging Core Facility, Medical faculty of University of Halle, Germany.
Andreas DeistungUniversity Clinic and Policlinic for Radiology, University Hospital Halle, University Medicine Halle, Germany; Halle MR Imaging Core Facility, Medical faculty of University of Halle, Germany.
Walter Alexander WohlgemuthUniversity Clinic and Policlinic for Radiology, University Hospital Halle, University Medicine Halle, Germany; Halle MR Imaging Core Facility, Medical faculty of University of Halle, Germany.
Ronny RedlichDepartment of Psychology, University of Halle, Germany; German Center for Mental Health (DZPG), Halle-Jena-Magdeburg, Germany; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg, Germany; Institute for Translational Psychiatry, University of Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSocial Anxiety Disorder (SAD) is a prevalent mental disorder characterized by altered processing of social stimuli. Intolerance of Uncertainty (IU) has been linked to social anxiety and influences the perception of social information. Yet, the neural correlates of IU in SAD during the processing of emotional stimuli remain insufficiently understood.

methodsIn this study, fMRI data were collected from 25 individuals with SAD and 25 healthy controls (HC), who completed a face processing task. Differential associations between the IU subdimensions prospective IU, inhibitory IU, and burden due to IU, brain activity, and functional connectivity were analyzed using full-factorial models. Functional connectivity measures focused on the insula.

resultsFor prospective IU, analysis of functional activity revealed an interaction effect in parietal regions and the insula (p

conclusionsThese findings indicate both disorder-specific and shared neural associations of IU. In particular, prospective IU may hold clinical relevance in SAD, as it is linked to reduced insular connectivity across groups but to increased neural activity exclusively in HC, possibly pointing toward neural vulnerabilities that could inform future approaches to the diagnosis and treatment of SAD.

Indexed as

Face processingfMRIFunctional connectivityInsulaIntolerance of uncertaintySocial anxiety disorder

Identifiers

PMID42810102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.