Evidence map›Paper›PMID 42809992›Full record

ArticleClinics (Sao Paulo, Brazil)2026

Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes-related mortality: a longitudinal study in U.S. adults.

Ao Li, Yuxin Pan, Mingcong Chen, Yang Meng, Yang Zhang, Mingyi Zhao, Lin Liu

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Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ao LiDepartment of pediatrics, The Third Xiangya Hospital of Central South University, Changsha Hunan, China.
Yuxin PanDepartment of pediatrics, The Third Xiangya Hospital of Central South University, Changsha Hunan, China.
Mingcong ChenDepartment of pediatrics, The Third Xiangya Hospital of Central South University, Changsha Hunan, China.
Yang MengDepartment of pediatrics, The Third Xiangya Hospital of Central South University, Changsha Hunan, China.
Yang ZhangDepartment of pediatrics, The Third Xiangya Hospital of Central South University, Changsha Hunan, China.
Mingyi ZhaoDepartment of pediatrics, The Third Xiangya Hospital of Central South University, Changsha Hunan, China.
Lin LiuDepartment of pediatrics, The Third Xiangya Hospital of Central South University, Changsha Hunan, China. Electronic address: liulin602243@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to explore the association between urinary Polycyclic Aromatic Hydrocarbons (PAHs) and diabetes prevalence and all-cause mortality in U.S. adults using data from 8,124 participants in the 2003-2014 NHANES cycles

methodsWeighted logistic regression and Cox proportional hazards models were employed to analyze the effects of individual and combined PAH metabolites. Confounders were adjusted, and nonlinear relationships were explored through restricted cubic splines.

resultsWeighted quantile sum regression revealed that co-exposure to six urinary PAHs was significantly associated with higher diabetes prevalence (OR = 1.131, 95% CI 1.008-1.269) and all-cause mortality (OR = 1.330, 95% CI 1.051-1.684), with 2-hydroxynaphthalene contributing most to diabetes risk and 1-hydroxynaphthalene to mortality risk within the mixture. In exploratory analyses of individual metabolites, nominal (unadjusted for multiple comparisons) positive associations were observed for ΣPAHs and 1-hydroxynaphthalene with diabetes prevalence. ΣPAHs also showed a modest association with all-cause mortality.

conclusionsThese findings suggest that PAH exposure is associated with a higher prevalence of diabetes and, among individuals with diabetes, higher all-cause mortality.

Indexed as

All-cause mortality among adults with diabetesDiabetesNHANEsPolycyclic aromatic hydrocarbonsWQS

Identifiers

PMID42809992
PMCPMC13653480

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