Evidence map›Paper›PMID 42809717›Full record

ArticleBJS open2026

Risk factors for idiopathic granulomatous mastitis: scoping review.

Rute S S Castelhano, Leah Argus, Daniel Ahari, Goonj Johri, Emma MacInnes, Shaneel Shah, Christopher Darlow, Vijay Sharma, Rudresh Shukla, Iain Lyburn and 3 more

Abstract readScoping Review
In one paragraph

Article in BJS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rute S S CastelhanoManchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.ORCID 0000-0002-9047-2276
Leah ArgusManchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.
Daniel AhariManchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.
Goonj JohriManchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.
Emma MacInnesDepartment of Surgery, Leeds Teaching Hospitals NHS Trust, UK.
Shaneel ShahManchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.
Christopher DarlowAntimicrobial Therapeutics and Pharmacodynamics, University of Liverpool, Liverpool, UK.
Vijay SharmaDepartment of Infectious Diseases and Microbiology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Rudresh ShuklaCentre for Musculoskeletal Research, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK.
Iain LyburnCobalt Medical Charity, Cheltenham, UK.
Nisha SharmaDepartment of Radiology, Leeds Teaching Hospitals NHS Trust, UK.ORCID 0000-0003-3991-0768
Roisin BradleyYork and Scarborough Teaching Hospitals, NHS Foundation Trust, York, UK.
Cliona C KirwanManchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.

Funding

Association of Breast Surgeons (UK) ResearchCobalt Medical CharityDevelopmentMasonic Charitable Foundation Chair of Surgical TrialsMasonic Charitable Foundation FellowshipRoyal College of Surgeons
6 · The paper itself

Abstract

backgroundIdiopathic granulomatous mastitis (IGM) is a rare, benign, inflammatory breast condition. The diagnostic challenge can cause delays in diagnosis and treatment. The quality of evidence for the diagnosis and management of IGM is low. A scoping review of existing literature was conducted to determine risk factors for IGM, with the aim of informing clinical suspicion, earlier diagnosis, and treatment of this condition.

methodsA scoping review of the MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases (2003-2023) was performed following PRISMA-ScR guidance. Data on demographics, reproductive history, hormonal factors, body mass index (BMI), and smoking were extracted and subjectively compared to appropriate published population demographics of the relevant risk factors.

resultsIn all, 230 studies involving 13 062 patients were included. Most common countries of publication origin were Turkey (86 papers; 5233 patients), the USA (30 studies; 764 patients), and China (23 papers; 3990 patients), with three papers (25 patients) from the UK. Most common ethnicities reported were Hispanic (36%), Turkish (20%), White (9%), and Middle Eastern (8%). The mean age (34.7 years) was consistent across the literature, except for UK publications (mean age 50 years). High rates of history of pregnancy (> 90%) were reported, except for UK papers (68%); 64-85% of patients had a history of lactation; and the prevalence of hyperprolactinaemia (reported in 18% of papers) was 5% (versus 0.4% in the general population). BMI appears to match age and country-equivalent BMIs, with no association with diabetes. Smoking association is inconclusive.

conclusionRisk factors for IGM appear centred on reproductive, hormonal, ethnicity, and possibly geographical factors, although the data are limited by inconsistent reporting, small study sizes, and retrospective study designs.

Indexed as

Granulomatous MastitisAdultFemaleHumansPregnancyRisk Factorsbreast inflammationepidemiologyethnicityhyperprolactinaemialactationreproductive history

Identifiers

PMID42809717
PMCPMC13623002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.