Trial reportPloS one2026
Exploring the relationship between HIV Testing frequency and sexual behavior, prevention prophylaxis use among MSM in Southern China.
Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The trial behind it
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to explore the association between HIV testing trajectories, sexual behavior characteristics and HIV exposure prevention prophylaxis use, to provide a basis for developing more precise HIV prevention strategies. STUDY
designThis analysis utilized pseudonymized data from a three-arm, open-label randomized controlled trial (RCT) conducted in Guangxi, China, between 2021 and 2023.
methodsThis prospective cohort study enrolled 327 participants from southern China. Longitudinal data-including HIV testing, sexual risk behaviors, and prophylaxis use (PrEP/PEP)-were collected at baseline and quarterly for one year. Group-based trajectory modeling (GBTM) was used to identify behavioral patterns, and person-years (PY) of follow-up were calculated to estimate incidence densities of PrEP/PEP use and STI occurrence.
resultsA total of 76.45% of men who have sex with men (MSM) received HIV testing less frequently than once every three months, and HIV self-testing (HIVST) was not significantly associated with increased rates of HIV testing (HT). In the HT model, MSM who underwent middle-frequency HT were less likely to report having fewer temporary sexual partners (OR 0.120, 95% CI 0.017-0.85, P = 0.034) and regular sexual partners (OR 0.502, 95% CI 0.267-0.943, P = 0.032). The use of PrEP increased with higher HT frequency, demonstrating a 3.39-fold (95% CI: 1.377-8.843, P = 0.008) increase in the middle frequency group and a 7.335-fold (95% CI: 2.505-21.475, P < 0.001) increase in the high frequency group compared to the low frequency group. PEP use also increased with higher HT frequency, showing a 6.129-fold (95% CI: 1.921-19.553, P = 0.002) increase in the high frequency group compared to the low frequency group.
conclusionsWhile frequent HIV testing demonstrates significant associations with increased sexual partner numbers, its role in facilitating consistent use of HIV exposure prevention prophylaxis remains clinically valuable.
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