Evidence map›Paper›PMID 42809550›Full record

ArticlePLOS global public health2026

Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional study.

Silvana Perez-Leon, Daniel Mendoza-Quispe, Maria Sofia Cuba-Fuentes, Juan Carlos Bazo-Alvarez, M Amalia Pesantes, Andrea Gaspar, Joseph R Zunt, Victor M Montori, Jose Armando Castillo, Eduardo Carcausto and 4 more

Abstract read
In one paragraph

Article in PLOS global public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Silvana Perez-LeonCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID https://orcid.org/0000-0003-4860-587X
Daniel Mendoza-QuispeCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID https://orcid.org/0000-0003-0174-5816
Maria Sofia Cuba-FuentesDepartment of Medicine, Faculty of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.
Juan Carlos Bazo-AlvarezCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID https://orcid.org/0000-0002-6169-8049
M Amalia PesantesCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Andrea GasparDepartment of General Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0002-4139-1840
Joseph R ZuntDepartments of Neurology, Global Health, Medicine (Infectious Diseases), and Epidemiology, University of Washington, Seattle, Washington, United States of America.
Victor M MontoriKnowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota, United States of America.ORCID https://orcid.org/0000-0003-0595-2898
Jose Armando CastilloCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID https://orcid.org/0000-0002-3349-6503
Eduardo CarcaustoFaculty of Medicine, Universidad de San Martín de Porres, Lima, Peru.ORCID https://orcid.org/0000-0003-1371-6393
Nelson DiazSchool of Medicine, Universidad Peruana Union, Lima, Peru.ORCID https://orcid.org/0000-0002-7833-2852
Keveen SalirrosasCorporate Medical Directorate, Clínica Médica Cayetano Heredia, Lima, Perú.
Pilar CornejoDepartment of Medicine, Faculty of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.
J Jaime MirandaCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID https://orcid.org/0000-0002-4738-5468

Funding

Using Burden of Treatment as a Clinical Indicator of Barriers to Multimorbidity Management in Peru: A Mixed Methods ApproachR21TW011740 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI CUBA , MARIA SOFIA · 2020 to 2021
$297k
FIC NIH HHS R21 TW011740
6 · The paper itself

Abstract

People with multiple long-term conditions (MLTC) in low-resource settings face high treatment burdens, influenced by healthcare access and quality disparities. The study aimed to compare the treatment burden among patients with MLTC across geographical locations and healthcare providers in Peru. We conducted a cross-sectional study conducted between June-October 2023 among outpatients aged ≥40 years with type 2 diabetes and ≥1 additional chronic condition, recruited from public and private healthcare facilities in urban Lima and semi-urban Tumbes, Peru. Treatment burden was assessed using the Multimorbidity Treatment Burden Questionnaire (MTBQ). Differences in median MTBQ scores by setting and healthcare provider were analyzed using regression models adjusting for capacity- and workload-related variables. Among 555 participants (55% female, mean age 62.4 ± 10.5 years), median MTBQ score was 27.1 (IQR 14.6-41.7). After adjustment, patients in semi-urban Tumbes had higher treatment burden than those in urban Lima (adjusted median difference 6.1 points; 95% CI 2.9 to 9.3), while patients receiving care in private facilities had lower treatment burden than those in public settings (-6.6 points; 95% CI -9.3 to -3.9). These findings highlight substantial inequalities in treatment burden by place and provider type, with implications for efforts to improve care delivery and reduce disparities for people living with MLTC.

Identifiers

PMID42809550
PMCPMC13623086

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.