ArticleProceedings of the National Academy of Sciences of the United States of America2026
Phosphoproteomic dysregulation promotes tumor proliferation in Cushing's disease.
David T Asuzu, Dhruval Bhatt, Dustin Mullaney, Debjani Mandal, Diana Nwokoye, Sheelu Varghese, Daniela Tortoza Lopez, Nikhil Ramavenkat, Kory Johnson, Abdel G Elkahloun and 11 more
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In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
21 authors.
David T AsuzuNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0000-0002-6229-3190 Dhruval BhattNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Dustin MullaneyNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0000-0003-1197-6976 Debjani MandalNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0000-0002-0230-6981 Diana NwokoyeDepartment of Neurosurgery, University of Texas Southwestern, Dallas, TX 75231.
Sheelu VargheseNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0009-0002-8214-3509 Daniela Tortoza LopezNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Nikhil RamavenkatNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Kory JohnsonDivision of Intramural Research, Bioinformatics Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0000-0002-6693-3378 Abdel G ElkahlounCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, Bethesda, MD20892.
Kenneth AldapeLaboratory of Pathology, National Cancer Institute, Bethesda, MD 20892.
Dragan MaricFlow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0000-0003-2912-7921 Clarisse QuignonCellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0009-0009-2681-775X Nasir MalikTranslational Neuroscience Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Joseph P SteinerTranslational Neuroscience Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Yan LiProteomics Core Facility, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0000-0003-3820-5960 Susan WrayCellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0000-0001-7670-3915 Christina TatsiSection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892.
Lynnette K NiemanSection on Translational Endocrinology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.ORCID 0000-0003-0534-8025 Prashant ChittiboinaNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.ORCID 0000-0001-9349-4756 Funding
Improved Diagnosis and Treatment of Cushing's DiseaseZIANS003150 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI CHITTIBOINA, PRASHANT · 2015 to 2025
$13.7MHHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NIH ZIA NS003150-09Intramural NIH HHS ZIA NS003150
6 · The paper itselfAbstract
Pituitary adenomas constitute up to 20% of primary brain tumors, yet somatic mutations are only found in 15% of pituitary adenomas. Epigenomic dysregulation has been proposed as a tumorigenic mechanism in pituitary adenomas causing Cushing's disease (CD). We created paired datasets of human CD adenomas and en-route margin adult human pituitary glands, and assayed their chromatin accessibility, DNA methylation, transcriptomic, proteomic, and phospho-proteomic landscapes. In CD adenomas, we found epigenetic reactivation of a neurodevelopmental phosphoprotein program typically lost in the postnatal pituitary gland. CD cells overexpressed
Indexed as
AdenomaPhosphoproteinsPituitary ACTH HypersecretionPituitary NeoplasmsAnimalsCell ProliferationDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMicePituitary GlandProtein Phosphatase 2ProteomeProteomicsPhosphoproteinsProtein Phosphatase 2ProteomeCushing’s diseaseepigenomicsmultiomephosphoproteomepituitary adenomas
Identifiers
PMID42809388
PMCPMC13643276
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