Evidence map›Paper›PMID 42809123›Full record

ArticleVirchows Archiv : an international journal of pathology2026

Sequential lymphoid neoplasms mimicking relapse of mediastinal grey zone lymphoma in a patient with germline variants in EP300 and PTPRK.

Maria J Tapken, Darius Juskevicius, Ilaria Balestri, Claudia Ruth Bollinger, Ilaria Alborelli, Sebastian Kurscheid, Lucian Cajacob, Niels Willi, Peter Häusermann, Stefan Dirnhofer and 1 more

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Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Maria J TapkenInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Darius JuskeviciusDiagnostic Hematology, Department of Laboratory Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Ilaria BalestriInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Claudia Ruth BollingerDivision of Oncology, Kantonsspital Baselland, Bruderholz, Switzerland.
Ilaria AlborelliInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Sebastian KurscheidInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Lucian CajacobUniversity of Basel, Basel, Switzerland.
Niels WilliInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Peter HäusermannUniversity of Basel, Basel, Switzerland.
Stefan DirnhoferInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Alexandar TzankovInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland. alexandar.tzankov@usb.ch.ORCID http://orcid.org/0000-0002-1100-3819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sequential lymphoid neoplasms are rare and diagnostically challenging, with a variable clonal relationship. Here we present the case of a 59-year-old woman with mediastinal grey zone lymphoma (MGZL), who, shortly after achieving complete remission, developed a subsequent cutaneous neoplasm. Comparative molecular studies were performed using high-throughput sequencing (HTS), which demonstrated that both neoplasms shared high-allele-frequency EP300:p.P2333L and PTPRK:p.R532K variants. In addition, each neoplasm harboured private, mutually exclusive variants-NFKBIA:p.R245Sfs*39 and BTG2:c.142+5G>C in the MGZL and JAK1:p.Q562* and JAK1:p.G1097D in the skin. Integrating the clinical course with HTS, we diagnosed lymphomatoid papulosis and excluded relapse of the MGZL. Interestingly, the shared variants were likely germline rather than clonal, suggesting they created a permissive background predisposing to two independent transforming events along the B- and T-cell lineages. Molecular studies may help to reveal the genetic basis of composite lymphomas and to resolve diagnostically discordant, complex presentations.

Indexed as

Brentuximab vedotinHigh-throughput sequencingLymphomatoid papulosisMediastinal grey zone lymphomaSequential lymphoid neoplasms

Identifiers

PMID42809123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.