Evidence map›Paper›PMID 42809102›Full record

ArticlePsychopharmacology2026

Moving beyond 5-HT

Praneet Suresh, Josie Kins, Lex Levkovskyy, Andrew Thieme, Paul Wren, Tom Ray, Frederick S Barrett, Robin Carhart-Harris, Danilo Bzdok

Abstract read
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In one paragraph

Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Praneet SureshMila - Quebec Artificial Intelligence Institute, Montréal, QC, Canada.
Josie KinsMindstate Design Labs, San Francisco, CA, USA.
Lex LevkovskyyMindstate Design Labs, San Francisco, CA, USA.
Andrew ThiemeMindstate Design Labs, San Francisco, CA, USA.
Paul WrenMindstate Design Labs, San Francisco, CA, USA.
Tom RayMindstate Design Labs, San Francisco, CA, USA.
Frederick S BarrettCenter for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Robin Carhart-HarrisDepartments of Neurology and Psychiatry, University of California-SF, San Francisco, CA, USA.
Danilo BzdokMila - Quebec Artificial Intelligence Institute, Montréal, QC, Canada. danilo.bzdok@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationalePsychedelics exhibit rapid, durable therapeutic effects across diverse psychiatric conditions, yet their broad-spectrum psychoactivity poses challenges for clinical translation.

objectivesAs a proof-of-concept, we aimed to quantify associations between 19 neurotransmitter receptors and the subjective effects of 21 psychedelic drugs with broadly assayed binding profiles.

methodsWe used a custom Global Vectors for Word Representation (GloVe)-based semantic embedding model trained on 4,496 firsthand experience reports and integrated it with receptor affinities to identify candidate receptor-linked semantic patterns related to distinct psychoactive effects without imposing predefined categorization systems.

resultsWhile 5-HT

Indexed as

Hypothesis generationNatural language processingPartial least squares regressionPsychedelicsReceptor binding profilesSubjective effects

Identifiers

PMID42809102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.