ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Dementia risk factors and biomarkers in subjective cognitive decline: real world evidence from the monza brain health service.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
aimsUp to 45% of dementia can be prevented by addressing modifiable risk factors. Brain Health Services (BHS) are emerging across Europe, targeting individuals with subjective cognitive decline (SCD) to assess, communicate and reduce their risk of dementia. Our aim is to characterize our BHS cohort, and assess differences in clinical, biological, neuroimaging, and impact of biomarker disclosure based on plasma Lumipulse p-Tau217.
methodsWe analyzed baseline data from 186 consecutive individuals seen at our BHS (132 SCD). Cumulative dementia risk was calculated using the total Lancet relative risk (RR). Participants were grouped in plasma Lumipulse p-Tau217 above and below 0.15 pg/mL (A + and A-). Cluster analysis was performed with k-means.
resultsThe most prevalent potentially modifiable factors among participants with SCD were sleep impairment, smoking, physical inactivity, and hypertension. A + SCD subjects (32%) were older and showed worse performance on cognitive screening tests (P DISCUSSION: Our findings showed a high prevalence of modifiable risk factors in SCD. A+ individuals demonstrated biological and structural hallmarks of early neurodegeneration. Biomarker disclosure was feasible, reflecting the potential benefits of transparent risk communication. These findings support incorporating plasma biomarkers and structured disclosure protocols in BHS, complementing multimodal prevention strategies to delay dementia onset.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.