Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Longitudinal data on health-related quality of life and its association with time to readmission in bladder perfusion patients.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo examine the relationship between health-related quality of life (HRQoL) and time to readmission in patients undergoing bladder perfusion, to explore the association of longitudinal changes and patterns of HRQoL at readmission, and to generate hypotheses for future interventions to prolong time to readmission.
methodsThis prospective observational study included 267 patients who underwent bladder perfusion at Shanghai General Hospital from August 2021 to January 2024. The SF-36 questionnaire was used to measure patients' health-related quality of life (HRQoL) at 1 week (T0) and 8 weeks (T1) after induction of bladder perfusion and to record information on readmission within 14 months. Cox proportional hazards regression models were constructed for readmission times at T0, T1, and T0-T1 change scores to analyze the ability of each HRQoL dimension to predict time to readmission.
resultsA total of 131 readmissions occurred, with an incidence rate of 49.1% and a median readmission time of 7.2 (IQR, 4.2-10.9) months. Physiological indicator dimensions were associated with time to readmission in the T0, T1, and T0-T1 models, and the strength of association for physiological indicators was significantly greater than that for psychological indicators (P = 0.023, < 0.001, and 0.017, respectively). In the T0 model, four of the ten SF-36 domains (Physical Component Summary [PCS], physical functioning, role-physical, and general health) showed statistically significant associations with time to readmission (all P < 0.05). In the T1 model, eight domains (all except bodily pain and mental health) were significantly associated. In the T0-T1 change model, six domains (PCS, physical functioning, role-physical, general health, role-emotional, and social functioning) were significantly associated. The number of significant domains varied across models because the strength of association between HRQoL and readmission time depends on the timing of assessment: post-treatment (T1) HRQoL showed the strongest associations, followed by change in HRQoL (T0-T1), while pre-treatment (T0) HRQoL showed the fewest significant associations. The HRQoL information collected at T1 had the strongest associations with readmission time, followed by change, and then T0 HRQoL information. Physiological indicators (PCS and its component domains) showed stronger associations than psychological indicators (MCS and its component domains).
conclusionHealth-related quality of life and its longitudinal changes are associated with time to readmission, with physiological and post-treatment indicators showing stronger associations. Longitudinal HRQoL information can be used to improve patient prognosis. Collecting HRQoL data during bladder perfusion may help guide interventions that prolong the interval to readmission. In light of these limitations, our results should be considered hypothesis-generating rather than definitive. The strong associations observed between HRQoL and readmission time warrant further investigation in studies with more comprehensive clinical data.
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