Trial reportOral health & preventive dentistry2026
Effect of Bletilla striata-Litsea cubeba Toothpaste on Clinical Indicators and Inflammatory Factor Levels in Gingival Crevicular Fluid in Patients with Biofilm-Induced Gingivitis: A Randomised Controlled Trial.
Trial report in Oral health & preventive dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
objectiveTo preliminarily evaluate the clinical efficacy of Bletilla striata-Litsea cube-batoothpaste in patients with plaque-induced gingivitis and its impact on inflammatory factors in gingival crevicular fluid. METHODS AND MATERIALS: In a randomised clinical trial, 80 patients with plaque-induced gingivitis were randomly allocated to receive either Bletilla striata-Litsea cubeba toothpaste (experimental group) or negative control toothpaste (control group). Following a 2-week washout period, periodontal indices including the Turesky-modified Quigley-Hein Plaque Index (TmQHI) and Sulcus Bleeding Index (SBI), along with inflammatory cytokines (IL-1β, IL-6, TNF-α) quantified from gingival crevicular fluid (GCF) samples of the right mandibular first molars, were assessed at baseline (0 week), 4, 8, and 12 weeks. Statistical analyses employed repeated-measures analysis of variance (ANOVA) for longitudinal comparisons and independent samples t-tests for inter-group comparisons at identical time points, with statistical significance defined as α = 0.05.
resultsThe experimental group exhibited significant TmQHI and SBI reductions at 8 and 12 weeks (p 0.05) versus delayed changes in controls. IL-1β decreased significantly at 8 and 12 weeks with lower levels than controls (p 0.05); IL-6 declined earlier in the experimental group, while TNF-α reductions were comparable between groups.
conclusionCompared with control, the novel toothpaste achieved earlier and greater improvements in periodontal indices and specific inflammatory mediator levels in plaque-induced gingivitis.
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