Evidence map›Paper›PMID 42808129›Full record

ArticleAPL bioengineering2026

Engineering of a wireless single capacitive discharge conductivity-clamped gene electrotransfer probe for naked nucleic acid therapeutics.

Keng-Yin Lai, Stephen L Mow, Mathumathi Manoharan, Anastasia Thiessen, Georg von Jonquieres, Jeremy L Pinyon, Edward N Crawford, Gary D Housley, Amr Al Abed, Nigel H Lovell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keng-Yin LaiSchool of Biomedical Engineering, UNSW, Kensington, NSW, Australia.ORCID https://orcid.org/0009-0005-3873-3941
Stephen L MowSchool of Biomedical Engineering, UNSW, Kensington, NSW, Australia.
Mathumathi ManoharanSchool of Biomedical Engineering, UNSW, Kensington, NSW, Australia.ORCID https://orcid.org/0009-0001-7775-6119
Anastasia ThiessenSchool of Biomedical Engineering, UNSW, Kensington, NSW, Australia.ORCID https://orcid.org/0009-0006-4704-0095
Georg von JonquieresSchool of Biomedical Sciences, UNSW, Kensington, NSW, Australia.ORCID https://orcid.org/0000-0002-7423-3355
Jeremy L PinyonSchool of Medical Sciences, University of Sydney, Camperdown, NSW, Australia.
Edward N CrawfordSchool of Biomedical Sciences, UNSW, Kensington, NSW, Australia.ORCID https://orcid.org/0000-0002-2158-1962
Gary D HousleySchool of Biomedical Sciences, UNSW, Kensington, NSW, Australia.ORCID https://orcid.org/0000-0002-8413-588X
Amr Al AbedSchool of Biomedical Engineering, UNSW, Kensington, NSW, Australia.ORCID https://orcid.org/0000-0002-5560-4771
Nigel H LovellSchool of Biomedical Engineering, UNSW, Kensington, NSW, Australia.ORCID https://orcid.org/0000-0003-1637-1079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulsed electric field gene electrotransfer addresses the need for safe, directed "vector-free" delivery of DNA/mRNA therapeutics in deep tissue targets. We report the development of a disposable needle-type "electro-lens" probe for precision delivery of DNA/mRNA to tissues via translocation of nucleic acids into cells using focused single-pulse electric fields. We developed and manufactured a novel ganged linear bionic electrode array enhanced by incorporating integrated microfluidics to deliver naked DNA expression cassettes in a low-conductivity carrier ("conductivity-clamping," CC). This system was packaged in a disposable wireless probe for single capacitive discharge conductivity-clamped gene electrotransfer (SCD-CC-GET), powered by an integrated capacitor with automated discharge mechanism. The electrode array was achieved by laser-etching parylene-insulated concentric stainless steel needles, with the lensing effect of the electric field tuned by varying the separation between elongated conductive elements. Our novel SCD-CC-GET probe is fully wireless and standalone, featuring integrated fluidics with minimal dead space, and an automated discharge mechanism. The probe was validated

Identifiers

PMID42808129
PMCPMC13619347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.