Evidence map›Paper›PMID 42808125›Full record

ArticleAPL bioengineering2026

Activation of cGAS-STING axis by CO@OMVs promote macrophage mitophagy for CIRI treatment.

Yiwei Chen, Shuntong Hu, Juan Huang, Pangyao Long, Jiahao Zhou, Longfeng Ran, Jinze Wu, Xiaobo Li, Huaizheng Liu, Yi Yuan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yiwei ChenDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Shuntong HuDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Juan HuangDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Pangyao LongDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Jiahao ZhouState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa 553000, Macau, China.
Longfeng RanDepartment of Neurology, Chengdu First People's Hospital, Chengdu 610041, China.
Jinze WuDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Xiaobo LiDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Huaizheng LiuDepartment of Emergency, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yi YuanDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Dujie XieDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.ORCID https://orcid.org/0009-0002-0364-8171

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the effects of nanobody-engineered bacterial outer membrane vesicles (CO@OMVs) on cGAS-STING-associated signaling, macrophage mitophagy, and cerebral ischemia-reperfusion injury (CIRI). Following extraction and characterization of CO@OMVs,

Identifiers

PMID42808125
PMCPMC13619348

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.