ArticleACG case reports journal2026
Gastrointestinal Manifestation of Light Chain Deposition Disease: Beware of the Snakeskin Duodenum.
Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Gastrointestinal manifestations of light chain deposition disease are exceedingly rare and are characterized by gastrointestinal bleeding, nutritional deficiencies and protein-losing enteropathy. Diagnosis is challenging due to nonspecific symptomatology and indolent disease progression. We describe the case of a 69-year-old woman presenting with melena, chronic diarrhea, and recurrent sepsis. Gastroscopy revealed a highly unusual snakeskin appearance of the duodenum, with histopathology and immunofluorescence confirming light chain deposition disease. This case highlights the importance of prompt biopsy acquisition, hematological evaluation and assessment of extragastrointestinal involvement in facilitating a timely diagnosis, particularly when an underlying lymphoplasmacytic lymphoma is a possible driver of disease.
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