ArticlePlastic and reconstructive surgery. Global open2026
A Prospective Split-face Trial Evaluating Skin Recovery and Enhancement with Polynucleotide (Rejuran) Following Fractional Needle Radiofrequency Treatment.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Fractional needle radiofrequency (FN-RF: Sylfirm-X) is a widely used energy-based treatment for skin rejuvenation, but it often disrupts the epidermal barrier and delays recovery. Polynucleotide (PN: Rejuran) injection has emerged as a recovery adjunct to promote post-RF healing. This study evaluates whether PN enhances skin barrier recovery when used immediately after FN-RF. Methods: A prospective, split-face clinical trial was conducted in 25 female patients 20-60 years of age. Immediately after treatment, 2 mL of PN was injected into right side, and 2 mL of normal saline was administered to the left side as a control. Skin parameters were objectively measured at baseline and 6 weeks after treatment, including pore size and wrinkle depth in 3-dimensional photography, transepidermal water loss and stratum corneum hydration, cutaneous elasticity, and sonographic dermal thickness. Patient-reported outcomes regarding redness resolution, burning sensation, and perceived improvements in pores, wrinkles, and elasticity were also collected. Results: PN-treated sides showed significantly greater improvement in pore score (Δ +4.79 versus +0.95, Conclusions: PN injection following FN-RF treatment significantly accelerates skin recovery, improves hydration, and enhances pore refinement compared to radiofrequency alone. PN serves as a clinically effective adjunctive therapy for optimizing postprocedural outcomes in aesthetic dermatology.
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