Tuning the pH-Responsive Properties of (2-Diisopropylamino) Ethyl Methacrylate-Based Cationic Nanoparticles: Toward Enhanced Nanoparticle Stability and Cytocompatibility.

Aaliyah Shodeinde, Olivia L Lanier, Shreya Nallaparaju, Michael Lam, Ani Savk, Nicholas A Peppas

Abstract read

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Article in Biomedical materials & devices (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Aaliyah ShodeindeMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.

Olivia L LanierInstitute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA.

Shreya NallaparajuInstitute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA.

Michael LamInstitute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA.

Ani SavkMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.

Nicholas A PeppasMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.

Funding

pH Sensitive Complex Hydrogels for Protein Drug ReleaseR01EB000246 · NIBIB · UNIVERSITY OF TEXAS AUSTIN · PI LOWMAN, ANTHONY M, PEPPAS, NICHOLAS A · 2002 to 2014

$3.8M

NIBIB NIH HHS R01 EB000246

6 · The paper itself

Abstract

Cationic nanoparticles have been widely investigated for their potent ability to transport therapeutic agents intracellularly. Previous studies in our lab have demonstrated that increasing network hydrophobicity in these polymers induces favorable pH-responsive phase transition and membrane-disruptive behavior for intracellular drug delivery. Building upon this idea, the work presented herein analyzes the physiochemical attributes and cargo delivery efficiency of a cationic nanoparticle system with the introduction with 2-(diisopropylamino)ethyl methacrylate (henceforth designated as DPAEMA), a comonomer heightening the hydrophobic content of the inner particle core. DPAEMA is a cationic, amine-containing monomer often introduced as an ionizable hydrophobic block to nanoparticles due to its high biocompatibility and ability to impart pH-sensitivity with a pK

Indexed as

BiomaterialsHydrogelsNanoparticlesProtein delivery

Identifiers

PMID42808097

DOI10.1007/s44174-023-00122-8

PMCPMC13619317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.