Evidence map›Paper›PMID 42808082›Full record

ArticleBarrier immunity2026

Neonatal Exposure to Antibiotics Triggers Obesity in Adulthood by Permanent Microbiota Dysbiosis and Reduction of Adipose Regulatory T Cells.

Peter Zanvit, Junji Xu, Wenjing Yang, Nancy Guo, Tianming Yu, Xue Jiao, Michaela Prochazkova, Wenwen Jin, Na Liu, Sang-A Park and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Barrier immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Peter ZanvitMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Junji XuMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Wenjing YangDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern University, Chicago, Illinois, USA.
Nancy GuoMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Tianming YuDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern University, Chicago, Illinois, USA.
Xue JiaoMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Michaela ProchazkovaDepartment of Transfusion Medicine, Center for Cellular Engineering, NIH, Bethesda, Maryland, USA.
Wenwen JinMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Na LiuMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Sang-A ParkMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Cheryl ChiaMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Daxesh P PatelCenter for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
Dunfang ZhangMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Nathan GoldbergMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Alexander CainMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.
Frank J GonzalezCenter for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Yingzi CongDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern University, Chicago, Illinois, USA.
WanJun ChenMucosal Immunology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-9335-2114

Funding

Immunotherapy of inflammation, autoimmune disease and cancer ZIADE000737 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI CHEN, WANJUN · 2021 to 2025
$3.8M
TGF-beta Regulation of Mucosal and Systemic T Cell Immunity and ToleranceZ01DE000101 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI CHEN, WANJUN · 2004 to 2008
$2.0M
Intramural NIH HHS Z01 DE000101Intramural NIH HHS ZIA DE000737
6 · The paper itself

Abstract

Neonatal dysbiosis of the gut microbiota represents a critical environmental factor promoting obesity, but the underlying immunological mechanisms remain unknown. We show here that neonatal treatment of mice with broad-spectrum antibiotics for the first 3 weeks of life (NeoATB) resulted in the development of obesity and metabolic abnormalities in adulthood. The NeoATB mice exhibited a permanent dysbiosis of gut microbiota, decreased CD4

Indexed as

inflammationintestinal permeabilitymicrobiota dysbiosisneonatal ageobesityST2TGFβ signalingTreg

Identifiers

PMID42808082
PMCPMC13618908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.